Hypercoagulability in COVID-19: Is there an antiphospholipid syndrome?

Background: Hypercoagulability has been established in COVID-19 and has been linked to thrombotic risk. The existence of an antiphospholipid (aPL) syndrome in COVID-19 remains controversial. Aim(s): Determine if markers of aPL syndrome are elevated in COVID-19 and associated with hypercoagulability and in-hospital clinical events. Method(s): Blood, urine, clinical data, and outcomes were analyzed in patients hospitalized with COVID-19 (n = 100) enrolled in the IRB approved TARGET-COVID study and in healthy subjects (n = 131). aPL syndrome was assessed using using lupus anticoagulant assays (dRVVT and Hex LA, Precision BioLogic Inc.);aPL antibody (APA) profiling (IgA,IgM,IgG) against aB2GP1, anticardiolipin (aCL), and anti-phosphotidyl serine (aPS) assays (Corgenix). Hypercoagulability, and coagulation markers (D-Dimer, Factor-V, VIII, XII, and Prekalikrein) were assessed using thromboelastography (TEG-6s), ELISA, and standard coagulation assays, respectively. Result(s): Mean age was 59 +/- 19 years;predominately African American (65%), with a high prevalence of hypertension (74%), obesity (53%), and diabetes (45%). LA positivity was observed in 2%;and 32%, 23%, and 9% by aB2GP1, aCL, and aPS antibody testing, respectively (Figure 1). Hypercoagulability defined by platelet-fibrin clot strength (MA >= 68 mm) was observed in 62% of the total group and was not associated with LA or APA positivity. Patients had lower FV, FXII, PK activity vs. healthy subjects (p < 0.05 for all). D-dimer was higher in patients with aPL's vs. negative patients (p = 0.03) but was not associated with thrombotic events (21% vs. 16%). Patients with positive aPS antibodies had higher mortality than aPS negative, and aCL positive, and aB2GP1 positive patients (44% vs. 18%, 10%, 7%;p< 0.05) respectively. Conclusion(s): Based on LA assay, aPL syndrome is infrequent in COVID-19. However, there is a high prevalence of aPL antibodies that correlate with D-dimer with the greatest prevalence observed for aB2GP1. aPS positivity correlated with mortality and deserves further investigation as a biomarker of poor outcomes. (Figure Presented).

Estimation some kidney function parameters among covid-19 patients in karbala province

Background: In cases with moderate to extreme respiratory system disorders, Corona Virus Disease 2019 (COVID-19) or SRAS-CoV-2 (Serious Coronavirus Acute Respiratory Syndromes 2) have also been involved. The aim of this research. The association between different hematologic parameters and the severity of COVID19. Experiment: A total of 184 patients with COVID-9 who were admitted to specialized kerbala Hospital for Internal in the kerbala province during the period from October 2020 till February 2021 Clinical and laboratory data of the patients were collected from medical records. Results Among them, 42 (22.8%), 88 (47.8%) patients were in the mild/moderate group, and 54 (29.3%) were in the severe/life-threatening group. the results of present study showed significant differences among blood parameters (urea, creatinine, ferittine and spo2).in different stage (mild, moderate and severe) of COVID 19 infection. CONCLUSION: The high prevalence of renal insufficiency in COVID-19 patients was observed in our research. The findings showed an important association between indices of renal function and distortions in various laboratory markers.

Skin allergies generated by rubber gloves and excessive soaps and sterilizers due to COVID-19 pandemic: A review

SUMMARY. The sanitizers and disinfectants have become widely used due to the COVID-19 global health crisis. However, as much as these household products keep us clean and prevent transmission of the virus, excessive use of these can be harmful. Recently, many kinds of disinfectants have been used with very in-tensive usage of the right ones, as well as the hands wearing duration, too many people developed redness of the skin some have sustained injuries with the incidence of red skin spots in addition to scratching and eyes irritation, arising question, why in which required an explanation. This article aims to demonstrate that excessive use of antiseptics and disinfectants along with the length of time in contact leading to skin allergies. Shows a significant skin irritation, whereas the skin is the first physical defense barrier against many kinds of pathogens and one of the components of the immune system against microorganisms. RESUMEN. Los sanitizantes y desinfectantes se han vuelto ampliamente utilizados debido a la crisis de salud global del COVID-19. Sin embargo, por mucho que estos productos domésticos nos mantengan limpios y eviten la transmisión del virus, el uso excesivo de estos puede ser perjudicial. Recientemente, se han utilizado muchos tipos de desinfectantes con un uso muy intensivo de los correctos, así como la duración del uso de las manos, de-masiadas personas desarrollaron enrojecimiento de la piel, algunas han sufrido lesiones con la incidencia de man-chas rojas en la piel además de rascarse e irritación de los ojos, pregunta que surge, que requiere una explicación. Este artículo tiene como objetivo demostrar que el uso excesivo de antisépticos y desinfectantes junto con el tiempo de contacto conduce a alergias cutáneas. Muestra una irritación cutánea significativa, mientras que la piel es la primera barrera de defensa física contra muchos tipos de patógenos y uno de los componentes del sistema inmunológico contra los microorganismos.